The first time Robert Heinzen tried to get Coxiella burnetii to grow by itself, he failed miserably. The bacterium, which causes an influenza-like illness called Q fever, normally divides only inside the cells it infects — forcing researchers to grow it in mammalian tissue and hampering their efforts to investigate the microbe. When Heinzen tried to find […]
Ageing is a regulated process in which hormones have pivotal roles. Crystal structures of two hormone co-receptors should be informative for drug discovery focused on age-related disorders. In Greek mythology, three goddesses known as the Fates govern the lifespan of each person. Klotho, Lachesis and Atropos are the spinner, the allotter and the cutter of […]
Human follicular helper T cells engaging in synaptic interactions with germinal centre B cells release dopamine stored in chromogranin B+ granules, causing rapid externalization of ICOS ligand, which in turn enhances CD40L delivery to the synaptic cleft and synaptic contact, and results in an accelerated response.