June 2015


TRANSCRIPTION: CHROMATIN REMODELING + MANIPULATION OF THE NUCLEOSOME (DNA/HISTONE COMPLEX) *****

►"...BAF BLOCKER: In normal embryonic stem cells (top panel), the chromatin remodeling complex esBAF moves nucleosomes into enhancer-flanking DNA regions (blue) to keep enhancers (red) free of nucleosomes so they can promote transcription of protein-coding genes. When esBAF is absent (lower panel), nucleosomes move out of the flanking regions and into the enhancer, freeing up noncoding RNA transcription that begins in the enhancer and continues into the flanking DNA..."
►"...Recent genome-sequencing work has revealed that enhancer regions not only promote the transcription of protein-coding genes, but can also contain the script for noncoding RNAs. Although noncoding RNAs are a hot topic, how they are regulated isn’t understood, says Toshio Tsukiyama of the University of Washington...."

—http://bit.ly/1GHa09o
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TRANSCRIPTION: CHROMATIN REMODELING + MANIPULATION OF THE NUCLEOSOME (DNA/HISTONE COMPLEX) *****

►...BAF BLOCKER: In normal embryonic stem cells (top panel), the chromatin remodeling complex esBAF moves nucleosomes into enhancer-flanking DNA regions (blue) to keep enhancers (red) free of nucleosomes so they can promote transcription of protein-coding genes. When esBAF is absent (lower panel), nucleosomes move out of the flanking regions and into the enhancer, freeing up noncoding RNA transcription that begins in the enhancer and continues into the flanking DNA...
►...Recent genome-sequencing work has revealed that enhancer regions not only promote the transcription of protein-coding genes, but can also contain the script for noncoding RNAs. Although noncoding RNAs are a hot topic, how they are regulated isn’t understood, says Toshio Tsukiyama of the University of Washington....

—http://bit.ly/1GHa09o