Researchers discover switch that converts blood vessels to blood stem cells!

A team of scientists in the UK and Italy has discovered a switch that instructs #blood vessel cells to become blood #stem cells during #embryonic development in mice. These findings could aid research into new blood cell creation for #transplants. Using single-cell technology, researchers from the Wellcome Sanger Institute in Cambridge and the European Molecular Biology Laboratory […]

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Blood-vessel-on-a-chip provides insight into new anti-inflammatory drug candidate

One of the most important and fraught processes in the human body is inflammation. Inflammatory responses to injury or disease are crucial for recruiting the immune system to help the body heal, but inflammation can also cause an increase in the production of thrombin, which can lead to dangerous blood clots and other conditions. Activated protein C (APC) is a naturally occurring anti-coagulant protein with anti-inflammatory and other protective effects that has been used medically to treat severe blood infections and wounds; however, its use is limited because its inhibition of thrombin also impacts the blood’s ability to clot, increasing bleeding risk.

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How Bacteria Help Regulate Blood Pressure | Quanta Magazine

Kidneys sniff out signals from gut bacteria for cues to moderate blood pressure after meals. Our understanding of how symbiotic microbes affect health is

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World’s First Artificial Kidney Is All Set To Replace Dialysis in 2-3 Years. Here is how it works !

A team of university scientists has developed the world’s first artificial kidney technology to be implanted in the body. Their bio-hybrid approach uses living kidney cells in tandem with a series of specialized microchips powered by the human heart to filter waste from the blood stream. The National Kidney Foundation estimates that over 100,000 patients are on the waiting list for a donor kidney, and over 3,000 are added list each year. The average patient spends 3.6 years waiting for a viable transplant, and may be treated with dialysis while they wait, but only one in three dialysis patient survives

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Blood testing via sound waves may replace some tissue biopsies

Scientists from MIT and other institutions have developed a microfluidic device that uses sound waves to isolate cellular packets called exosomes from blood samples, which could be used to diagnose diseases such as cancer or fetal abnormalities.

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Insilico Medicine launches Aging.AI — deep-learned predictor of age trained on blood tests

Insilico Medicine launched aging.AI, a system allowing users to guess their age and gender by entering the results of their blood test.

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Cancer-associated mutations are common in patients with unexplained low blood counts

Patients with unexplained low blood counts and abnormally mutated cells who do not fit the diagnostic criteria for recognized blood cancers should be described as having clonal cytopenias of undetermined significance (CCUS), suggest University of California, San Diego School of Medicine researchers in a recent paper published in the journal Blood. The researchers found the condition surprisingly common in older patients with low blood counts.

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Targeted drug delivery with these nanoparticles can make medicines more effective

Nanoparticles disguised as human platelets could greatly enhance the healing power of drug treatments for cardiovascular disease and systemic bacterial infections. These platelet-mimicking nanoparticles, developed by engineers at the University of California, San Diego, are capable of delivering drugs to targeted sites in the body-particularly injured blood vessels, as well as organs infected by harmful bacteria. Engineers demonstrated that by delivering the drugs just to the areas where the drugs were needed, these platelet copycats greatly increased the therapeutic effects of drugs that were administered to diseased rats and mice.

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Simple method turns human skin cells into immune-fighting white blood cells – Salk Institute for Biological Studies

LA JOLLA-For the first time, scientists have turned human skin cells into transplantable white blood cells, soldiers of the immune system that fight infections and invaders. The work, done at the Salk Institute, could let researchers create therapies that introduce into the body new white blood cells capable of attacking diseased or cancerous cells or augmenting immune responses against other disorders.

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Scientists use 3D printing to make artificial blood vessels

The tangled highway of blood vessels that twists and turns inside our bodies, delivering essential nutrients and disposing of hazardous waste to keep our organs working properly has been a conundrum for scientists trying to make artificial vessels from scratch. Now a team from Brigham and Women’s Hospital (BWH) has made headway in fabricating blood vessels using a three-dimensional (3D) bioprinting technique.