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Blood-vessel-on-a-chip provides insight into new anti-inflammatory drug candidate

One of the most important and fraught processes in the human body is inflammation. Inflammatory responses to injury or disease are crucial for recruiting the immune system to help the body heal, but inflammation can also cause an increase in the production of thrombin, which can lead to dangerous blood clots and other conditions. Activated protein C (APC) is a naturally occurring anti-coagulant protein with anti-inflammatory and other protective effects that has been used medically to treat severe blood infections and wounds; however, its use is limited because its inhibition of thrombin also impacts the blood’s ability to clot, increasing bleeding risk.

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Light-Triggered Genes Reveal the Hidden Workings of Memory | Quanta Magazine

Nobel laureate Susumu Tonegawa’s lab is overturning old assumptions about how memories form, how recall works and whether lost memories might be restored from

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Doctors are gene editing inside the body of a living human for the first time

Brian Madeux’s life hasn’t been easy. So far, he’s had 26 operations to fix problems in everything from hernias to eyes. He has a rare disease called Hunter syndrome, which is caused by the lack of a gene that’s used to produce an enzyme that breaks down certain carbohydrates. As a result, the carbohydrates build up…

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World’s First Artificial Kidney Is All Set To Replace Dialysis in 2-3 Years. Here is how it works !

A team of university scientists has developed the world’s first artificial kidney technology to be implanted in the body. Their bio-hybrid approach uses living kidney cells in tandem with a series of specialized microchips powered by the human heart to filter waste from the blood stream. The National Kidney Foundation estimates that over 100,000 patients are on the waiting list for a donor kidney, and over 3,000 are added list each year. The average patient spends 3.6 years waiting for a viable transplant, and may be treated with dialysis while they wait, but only one in three dialysis patient survives

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Bioengineered Lungs With Intact Blood Vessels Just Came One Step Closer to Reality

A group of researchers at Columbia University’s School of Engineering and Applied Science have successfully developed the first functional vascularised lung scaffold, and it could dramatically change how lung disease is treated.

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Scientists Have Uncovered The Atomic Structure of a Key Alzheimer’s Protein For The First Time

For the first time, scientists have revealed the chemical structure of one of the key markers of Alzheimer’s disease, capturing high-resolution images of the abnormal tau protein deposits suspected to be behind Alzheimer’s and other neurodegenerat

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The Adult Brain Can Regenerate Neurons in an Unexpected Area, Says New Study

Scientists have discovered for the first time that adult mouse brains produce new cells in the amygdala, a finding that could eventually lead to better treatments for conditions like anxiety and depression, as well as a better understanding of the

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A Silicon Valley scientist and entrepreneur who invented a drug to explode double chins is now working on a cure for aging

Nathaniel David’s father began suffering from the symptoms of early-onset osteoarthritis in his back during his teenage years. The 77-year-old is now stooped over, effectively crippled, and unable to move. David started feeling muscle tightness in his back two years ago, at age 47.  An MRI confirmed what he knew was his likely genetic fate: He…

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For the First Time Ever, We Can See Inside Living Cells Without Damaging Them

Researchers have developed a new ultrasound technique that allows them to see inside living cells at a scale that was previously unachievable without damaging the cells. Because the examined cells remain undamaged, they can be put back into the body, potentially leading to new treatment options for diseases or even defenses against aging.

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Nobel Prize predictions see honors for gene editing technology

Scientists behind the discovery of a technology called CRISPR-Cas9 that allows researchers to edit virtually any gene they target are among the top contenders for Nobel prizes next month, according to an annual analysis by Thomson Reuters.

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Nano-engineering enhances charge transport, promises more efficient future solar cells

(Phys.org) -Solar cells based on semiconducting composite plastics and carbon nanotubes is one of the most promising novel technology for producing inexpensive printed solar cells. Physicists at Umeå University have discovered that one can reduce the number of carbon nanotubes in the device by more than 100 times while maintaining exceptional ability to transport charges. This is achieved thanks to clever nano-engineering of the active layer inside the device. Their results are published as front page news in the journal Nanoscale.

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Fiber optic light pipes in the retina do much more than simple image transfer

(Phys.org) -Having the photoreceptors at the back of the retina is not a design constraint, it is a design feature. The idea that the vertebrate eye, like a traditional front-illuminated camera, might have been improved somehow if it had only been able to orient its wiring behind the photoreceptor layer, like a cephalopod, is folly. Indeed in simply engineered systems, like CMOS or CCD image sensors, a back-illuminated design manufactured by flipping the silicon wafer and thinning it so that light hits the photocathode without having to navigate the wiring layer can improve photon capture across a wide wavelength band. But real eyes are much more crafty than that.