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Blood-vessel-on-a-chip provides insight into new anti-inflammatory drug candidate

One of the most important and fraught processes in the human body is inflammation. Inflammatory responses to injury or disease are crucial for recruiting the immune system to help the body heal, but inflammation can also cause an increase in the production of thrombin, which can lead to dangerous blood clots and other conditions. Activated protein C (APC) is a naturally occurring anti-coagulant protein with anti-inflammatory and other protective effects that has been used medically to treat severe blood infections and wounds; however, its use is limited because its inhibition of thrombin also impacts the blood’s ability to clot, increasing bleeding risk.

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RNA carried by new nanoparticles can silence genes in many organs, could be deployed to treat cancer

RNA interference (RNAi), a technique that can turn off specific genes inside living cells, holds great potential for treating many diseases caused by malfunctioning genes. However, it has been difficult for scientists to find safe and effective ways to deliver gene-blocking RNA to the correct targets.